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KMID : 0644120040170030001
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Journal of Oriental Gynecology
2004 Volume.17 No. 3 p.1 ~ p.13
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The Experimental Study on Antithrombotic Effect of Mokdansan
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Park Min-Joung
Lee Bo-La
Lee Jung-Eun
Yoo Dong-Youl
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Abstract
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This study was performed to evaluate antithrombotic action of Mokdansan(MDS) which has effects of activating blood and removing thrombus. The results were obtained as follows MDS significantly inhibited platelet aggregation indu ced by ADP and epinephrine when analyzed by the Sigmoid Emax model in WinNonlin. EC50 values of MDS were 0.16 mg/ml and 15.59 mg/ml for ADP and epinephrine respectively. MDS showed fibrinolytic activity insignificantly as compared with the control group. MDS increased blood flow rate significantly as compared with the control group in vitro, but insignificantly as compared with the control group in vivo. MDS inhibited pulmonary embolism induced by collagen and epinephrine (inhibitive rate 50 %). MDS increased number of platelet, fibrinogen amount and shortened prothrombin time, activated partial thromboplastin time significantly as compared with the control group in thrombus model induced by dextran.
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KEYWORD
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